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Calcium formate as a supplement to prevent neural tube defects
Problem
Neural tube defects (NTDs) are devastating birth defects that occur very early during gestation. We now understand that folic acid is crucial for the development of the neural tube, and prenatal vitamin formulations contain additional folic acid to ensure sufficient levels of this important vitamin in women who are pregnant or preparing to...
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Lung mucus-penetrating peptides
Problem
Nucleic acid therapy has the potential to treat genetic diseases that affect the lungs. In order to effectively deliver genetic material to lung cells, gene delivery systems must be able to overcome the mucus barrier and directly target cells harboring the genetic mutation causing the disease state. Past efforts have focused to penetrate the...
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Repurposing Tamoxifen to treat lethal E. coli infections
ProblemOver 100,000 people suffer from Shiga toxin-producing E. coli infections every year which cause gastrointestinal illness. In 5% to 15% of cases, these toxins enter the bloodstream, which can result in fatal renal disease. These infections are currently untreatable, as traditional antibiotics induce higher toxin concentrations and worsen illness....
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Potent broad-spectrum antiviral for COVID-19 treatment
Unmet need Broad-spectrum antiviral drugs like remdisivir and niclosamide are promising treatments for COVID-19. Multiple clinical studies of remdisivir have shown benefits such as reduced recovery time. However, in November of 2020 the WHO recommended against the use of remdisivir for COVID-19 treatment based on questions of effectiveness. There remains...
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