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Revolutionizing drug delivery: smart hydrogels for precise nanoparticle and siRNA intestinal release
Background
Intelligent hydrogels, specifically environmentally responsive hydrogels, are emerging as promising biomaterials capable of responding to biological environments and processes. These materials offer tunability and biocompatibility, making them valuable for various biomedical applications, including tissue regeneration and controlled...
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Advancing prostate cancer chemoprevention
Evaluating the bioavailability and microbiome modulation of
a curcumin and ursolic acid combination therapy
Background
Prostate cancer (PCa) remains a significant health concern, necessitating effective chemoprevention strategies. However, no approved chemopreventive agents exist, highlighting the need for innovative approaches. This study aimed to...
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Unlocking the brain: boosting CNS accumulation of glioblastoma drugs
Problem
In the pursuit of optimizing the delivery of brain-penetrating drugs, researchers have explored innovative technologies to enhance their accumulation within the central nervous system (CNS). Traditional strategies such as altering drug chemistry or formulation have shown limited success in extending patient survival, particularly in the context...
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Method for dry powder inhaled delivery of clofazimine
Problem
Clofazimine is highly active against a multitude of bacteria that affect the lungs; however, oral delivery of this drug is hindered by the unpredictable bioavailability and pharmacokinetics of clofazimine. Orally administered clofazimine can cause systemic toxicity, with undesirable side effects including GI complications and hyperpigmentation...
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Fast-acting testosterone nasal spray
Background
Testosterone replacement therapy is a standard treatment for low testosterone levels in men. The estimated prevalence of testosterone deficiency in the United States ranges from 5.6% to 6.5%. Current therapies are applied either transdermally, via intra-muscular injection (IM), or intra-nasally using an oil-based gel. According to Harvard...
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Engineered methyltransferase for microbial production of the Alzheimer’s drug galantamine
Problem
Galantamine is a cholinesterase-inhibiting compound used for the treatment of cognitive decline in mild to moderate cases of Alzheimer’s disease and other memory impairment disorders. Galantamine is a plant alkaloid found in the bulbs and flowers of several species including daffodils, snowdrops, and red spider lilies. Galantamine...
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Blood-brain barrier penetrating peptides
Problem
Effective delivery of therapeutics into the brain is challenging, due to biological barriers including the blood-brain barrier (BBB), the perivascular space, cerebrospinal fluid, and the extracellular matrix. Drugs that can cross the BBB may be delivered intravenously; for drugs that cannot penetrate the BBB, intrathecal or local administration...
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Potent broad-spectrum antiviral for COVID-19 treatment
Unmet need Broad-spectrum antiviral drugs like remdisivir and niclosamide are promising treatments for COVID-19. Multiple clinical studies of remdisivir have shown benefits such as reduced recovery time. However, in November of 2020 the WHO recommended against the use of remdisivir for COVID-19 treatment based on questions of effectiveness. There remains...
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