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Improved drug delivery for solid tumors
A novel formulation paving the way for pancreatic cancer therapeutics Problem Pancreatic cancer therapeutics have a success rate of less than 8%. The solid nature of the tumor in pancreatic cancer renders the current standard of care, chemotherapy drugs, less effective. Unfortunately, the problem lies not with the drugs themselves, but with the drug...
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Repurposing Tamoxifen to treat lethal E. coli infections
ProblemOver 100,000 people suffer from Shiga toxin-producing E. coli infections every year which cause gastrointestinal illness. In 5% to 15% of cases, these toxins enter the bloodstream, which can result in fatal renal disease. These infections are currently untreatable, as traditional antibiotics induce higher toxin concentrations and worsen illness....
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Use of drug solvates in thermal processes to make solid dispersions at lower processing temperature
An improved manufacturing approach expands possibilities for poorly soluble drugs Description Increasing the solubility and bioavailability of poorly water-soluble drug candidates is critical to successful drug development and translation. While 90% of drug candidates in development and 40% of all marketed drugs exhibit poor solubility, this remains...
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DosePlus: A pharmaceutical 3D-printing platform for flexible and precise dosages
Problem Innovations in 3D printing have caused a paradigm shift in the design and manufacture of pharmaceuticals. By allowing for on-demand production of custom dosages, 3D printing has the potential to transform the field of personalized medicine and the economics of pharmaceutical manufacturing.1 However, existing 3D printing techniques for drug manufacturing...
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High-throughput screening platform for skin penetration and permeability for dermal drugs and skin care products
Description The skin is one of the most readily accessible tissues for delivery of drugs and therapeutics. Improving skin permeation and retention is a major focus for new drugs and skin care products. In the development stage of transdermal drugs, it’s important to probe permeability and test delivery methods in a high-throughput, cost-effective,...
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Enhanced dissolution of drug compositions using porous carriers made by thermal process
New pharmaceutical manufacturing process improves bioavailability of poorly soluble drugs Description Solubility of pharmaceuticals is crucial to absorption by the human intestine and, ultimately, efficacy of the drug. Over 90% of new chemical entities being considered for drug development have low solubility. Amorphous solid dispersions (ASDs) are...
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