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Deep learning for rapid and robust fluorescence lifetime imaging
Deep-learning approach has the potential to unlock fluorescent lifetime imaging for clinical applications. Fluorescence lifetime imaging microscopy (FLIM) is a widely used tool for biomedical imaging that offers many unique advantages over typical intensity-based fluorescence microscopy. FLIM is advancing fundamental biological research by enabling...
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New MRI acquisition and post-processing technique for improved breast cancer diagnosis
New computational imaging platform can improve patient-specific characterization of breast cancerProblemClinicians rely on imaging to direct the path of treatment for breast cancer. The current standards for vascular imaging, MRI and CT, can miss valuable information. Fortunately, there has been a wave of technical progress with digital health technologies....
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Observing single nanoparticle collisions at ultramicroelectrodes
Technology description
Metal nanoparticles (NPs) have been of interest in many fields, often because of their large surface-to-volume ratio and size dependent optical properties. Most research on NPs has focused on ensemble-averaged properties, but there have been investigations of the electrochemical behavior of an immobilized single NP, despite the...
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At-home diagnostic system for managing heart failure
Background
In the past year, we have seen widespread adoption of at-home and drive-through diagnosis. Dispersion of the first line of healthcare is creating a massive opportunity to lower healthcare costs and improve disease management for millions of patients. With more than 5 million patients in the United States and 11 million physician visits each...
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Bacterial reagents: stable, low-cost, readily available reagents with no purification requirements
Problem Most molecular biology techniques commonly used in research, biotechnology, healthcare, and education rely heavily on purified functional protein reagents. However, purification of these protein reagents requires substantial investment of time, expertise, equipment, and infrastructure. As a result, this significantly limits the availability...
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Diagnosis of lung cancer subtypes using rapid molecular test
New cancer subtyping system can improve treatment options without disrupting clinical workflow.Problem Lung cancer is the leading cause of cancer death, with over 100,000 people dying per year.1 As most tumors are inoperable by the time the cancer is detected, patients are increasingly being placed on tailored treatment regimens. Prescribing targeted...
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Br512: an improved DNA polymerase for isothermal amplification assays
Unmet need Loop-mediated isothermal amplification (LAMP) is a technique that allows for nucleic acid amplification without the need for a thermocycler. This technology enables testing for infections practically anywhere. Testing shortages have exacerbated the COVID-19 pandemic, and there is a high demand for tests that can provide rapid results outside...
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Sensitivity enhancement for diagnostic assays
Problem The COVID-19 pandemic has ushered in a new era of diagnostic testing. Patients now demand rapid results, and they want testing to happen in a safe and convenient setting. Regulatory agencies and the biotech industry are working together to meet this need. Fierce competition is emerging among the hundreds of tests that have now received Emergency...
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Early detection of cancer from blood draw
Problem Eight million people die from cancer each year, and 90% of these deaths happen in cases where the cancer has spread throughout the body from the initial tumor site.1 In the early stages of cancer, tumor cells can shed from the primary mass and enter the bloodstream. Clinicians can glean important information about the tumor from these circulating...
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Rapid screening tool to detect early-stage diabetes
New device with potential to improve diabetes care and management for millions of patients Problem The CDC estimates that approximately 7 million people in US have diabetes and don't know it.1 Delayed diagnosis increases the risk of serious complications such as premature heart disease, stroke, and kidney failure.2 Accurate screening tools that fit...
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