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Lipid nanocarriers for promoting angiogenesis
This invention describes a new way to deliver a protein called transmembrane stem cell factor (tmSCF) using tiny carriers made of lipids (fats). This helps promote the growth of new blood vessels and could treat peripheral vascular disease.
Background
Peripheral vascular disease (PVD) affects a significant portion of the aging population, often leading...
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Mechanical conditioning for mesenchymal stem cell rejuvenation
This technology uses mechanical force to rejuvenate aged stem cells. It enhances cell function, reduces aging markers, and improves DNA repair, making the cells more suitable for regenerative therapies.
Background
Mesenchymal stem cells (MSCs) hold immense promise for regenerative medicine due to their availability, multipotency, and immunomodulatory...
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Blood-brain barrier penetrant therapeutic delivery with biomacromolecule-tagged constructs
This technology uses nanoscale constructs tagged with biomacromolecules like peptides, nucleic acids, and carbohydrates to deliver therapeutic agents across the blood-brain barrier, enhancing drug delivery to the brain while minimizing off-target effects.
Background
The blood-brain barrier (BBB) is a critical physiological structure that serves to...
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Hydrogel matrix technology for accelerating tissue-engineered dermal and vascular formation
A tissue-engineered dermal equivalent uses a hydrogel matrix with two distinct layers and mesenchymal stem cells (MSCs). One layer promotes blood vessel cell formation, while the other encourages dermal fibroblast development, facilitating vascular and dermal tissue creation from a single stem cell source.
Background
Severe skin injuries, such as...
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A pharmaceutical compound for targeted cancer therapy using nucleobase analog derivatives with omega-3 fatty acids
The invention describes compounds combining nucleobase analogs with omega-3 fatty acids, enhancing cancer treatment efficacy, particularly for pancreatic cancer. These compounds improve stability and solubility and demonstrate significant anti-cancer activity, offering potential for targeted therapy.
Background
Pancreatic cancer presents a significant...
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Targeting protein palmitoylation to suppress tumor growth and metastasis in triple negative breast cancer
Flotillin-1 palmitoylation is essential for its stability and tumor-promoting functions in triple-negative breast cancer (TNBC). Disrupting this process, either genetically or with targeted inhibitors, reduces tumor growth and metastasis, making it a potential therapeutic target.
Background
Triple negative breast cancer (TNBC) is a particularly aggressive...
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Improved drug delivery for solid tumors
A novel formulation paving the way for pancreatic cancer therapeutics Problem Pancreatic cancer therapeutics have a success rate of less than 8%. The solid nature of the tumor in pancreatic cancer renders the current standard of care, chemotherapy drugs, less effective. Unfortunately, the problem lies not with the drugs themselves, but with the drug...
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