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Biomimetic high-strength bone implant polymer material
Problem
Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
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Recognitive hydrogel technology for precise molecular detection
Background
The field of chemical sensor technology has long sought methods to accurately detect and measure molecular presence and concentration in various environments. A pervasive challenge has been developing sensors that can selectively recognize specific molecules in complex mixtures. Traditional sensors often struggle with non-specific binding,...
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Chameleon NanoCluster Beacons for single N6-adenosine methylation detection
Problem
N6-methyladenosine (m6A) is the most prevalent modification found on eukaryotic mRNA. This modification is implicated in the development of cancer, stem cell differentiation, control of circadian rhythm, and more. m6A bases cannot be detected directly by sequencing, because the m6A modification does not change the base pairing properties and...
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BioPod: A platform for increasing efficiency and reducing costs of biomanufacturing
Problem statement Biology can be harnessed to produce a large share of the global economy’s physical materials, potentially with improved performance and sustainability. Fermentation, for centuries used to brew beer and make bread, is now being used to create high-value ingredients such as collagen and spider silk. According to McKinsey, biologically...
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A dissolvable biomaterial scaffold for generating aligned cell sheets
Background Generating cell sheets for tissues including cardiac, vascular, muscle, neural, and cartilage that require anisotropic aligned cell orientation relies on the use of biomaterial scaffolds. Currently available biomaterial matrices that are used as scaffolds for tissue growth remain tightly associated with the cells which can impede downstream...
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