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First-in-class blood-based diagnostic panel for depression and suicide risk
Background
The instinct to stay alive and maintain well-being is fundamental to all of us, yet nearly a million lives are lost to suicide each year around the world, presenting a significant public health challenge. Despite ongoing efforts, effectively identifying the risk and preventing suicide remains a complex issue. Biologically, suicide often...
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Patient-specific prostate cancer progression prediction model to inform personalized treatment
Problem
Prostate cancer is a significant health problem worldwide, and there is a vital need for accurate predictive models of disease progression to aid in effective treatment planning. Current models are largely statistical, based on a population of patients, and neglect the patient’s unique attributes. There is a significant need for more...
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Sono-optogenetics: A non-invasive optogenetic platform
Problem
Optogenetics is the light-dependent control of genetically modified neurons. Neuronal cells that express microbial opsins can transport ions in a light-gated process. Optogenetics has been used to treat disorders including vision loss in humans. Animal studies indicate that optogenetic therapies have applications in neurological disorders including...
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Treatment of manganese toxicity and manganese-induced Parkinsonism
Problem
Parkinsonian disorders are the second most common neurodegenerative disease in the United States, with no definitive treatment option available. Exposure to the metal manganese has been shown to be a major cause of parkinsonism.
Solution
Dr. Somshuvra Mukhopadhyay and his team have developed a pharmaceutical method for the management of manganese-induced...
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Production of Lu-177 and other radionuclides
Problem
Lu-177 is a radioactive isotope in high demand as a therapeutic for treatment of several types of cancer and may have other nuclear medicine applications. Current estimates are that the demand for Lu-177 will exceed 190,000 doses per year by 2023. No carrier added Lu-177 is produced by irradiation of enriched Yb in a nuclear reactor followed...
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