Search results for life+sciences+%3e+therapeutics+%3e+drug+delivery

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Future drug-delivery system to treat brain tumors
Background/problem Glioblastoma (GBM) is the most common malignant, primary brain tumor observed in adults, occurring at an incidence rate of 3.19 per 100,000 persons in the United States in 2017. Even with complete surgical resection of the tumor and adjuvant chemotherapy, these tumors often reoccur, resulting in a median survival of ~15 months. Part...
Inhaled formulations of the NSAID indomethacin
Background Patients suffering from headache and migraine have a limited list of thera­peutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...
Advancements in pulmonary antibiotic delivery: innovations for multidrug-resistant infections
Background Antibiotics like Tigecycline are vital for combating bacterial infections, but their intravenous delivery restricts usage to healthcare facilities, limiting options for patients outside such settings. The rise of multidrug-resistant respiratory infections, like those caused by S. maltophilia, necessitates innovative delivery approaches....
Convection-enhanced thermo-chemotherapy catheter system (CETCS)
Background Dr. Christopher Rylander, Associate Professor of Mechanical Engineering at UT Austin, and his team have pioneered the development of the Convection-Enhanced Thermo-Chemotherapy Catheter System (CETCS) to address the challenges in glioblastoma treatment. Dr. Rylander's expertise in biomechan­ical engineering, manufacturing, and design...
Revolutionizing drug delivery: smart hydrogels for precise nanoparticle and siRNA intestinal release
Background Intelligent hydrogels, specifically environmentally responsive hydrogels, are emerging as promising biomaterials capable of responding to biological environments and processes. These materials offer tunability and bio­compatibility, making them valuable for various biomedical applications, including tissue regeneration and controlled...
Unlocking the brain: boosting CNS accumulation of glioblastoma drugs
Problem In the pursuit of optimizing the delivery of brain-penetrating drugs, researchers have explored innovative technologies to enhance their accumulation within the central nervous system (CNS). Traditional strategies such as altering drug chemistry or formulation have shown limited success in extending patient survival, particularly in the context...
Real-time breath adaptive nebulizer for optimal pulmonary drug delivery
Problem Nebulizers produce an inhalable mist for localized drug delivery and are used to treat lung diseases including COPD and cystic fibrosis. The mist produced by the nebulizer is composed of droplets of a defined size, and droplet size and velocity dictate the efficiency of nebulized drug delivery. Currently available commercial nebulizers utilize...
Method for dry powder inhaled delivery of clofazimine
Problem Clofazimine is highly active against a multitude of bacteria that affect the lungs; however, oral delivery of this drug is hindered by the unpredictable bioavailability and pharmacokinetics of clofazimine. Orally administered clofazimine can cause systemic toxicity, with undesirable side effects including GI complications and hyperpigmentation...
Fast-acting testosterone nasal spray
Background Testosterone replacement therapy is a standard treatment for low testosterone levels in men. The estimated prevalence of testosterone deficiency in the United States ranges from 5.6% to 6.5%. Current therapies are applied either transdermally, via intra-muscular injection (IM), or intra-nasally using an oil-based gel. According to Harvard...
Blood-brain barrier penetrating peptides
Problem Effective delivery of therapeutics into the brain is challenging, due to biological barriers including the blood-brain barrier (BBB), the perivascular space, cerebrospinal fluid, and the extracellular matrix. Drugs that can cross the BBB may be delivered intravenously; for drugs that cannot penetrate the BBB, intrathecal or local administration...

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