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Covalent ERK inhibitors for suppressing cancer
BI-78D3, a small molecule, covalently binds to ERK1/2’s D-recruitment site, disrupting ERK signaling crucial for cancer cell growth. This shows promise for treating ERK-dependent cancers, including those resistant to BRAF inhibitors.
This disrupts ERK signaling crucial for cell proliferation and survival, particularly in certain cancers like...
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Lipid nanocarriers for promoting angiogenesis
This invention describes a new way to deliver a protein called transmembrane stem cell factor (tmSCF) using tiny carriers made of lipids (fats). This helps promote the growth of new blood vessels and could treat peripheral vascular disease.
Background
Peripheral vascular disease (PVD) affects a significant portion of the aging population, often leading...
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Cellulose nanofiber spray for enhanced filtration efficiency
This invention is a water-soluble, biodegradable, and biocompatible spray composed of cellulose nanofibers and polyvinyl alcohol that enhances the filtration efficiency of textiles by creating a protective layer that can break the membranes of pathogens.
Background
The need for effective filtration systems, particularly in personal protective equipment...
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Multifunctional iron chelators to combat antibiotic resistance and enable bacterial imaging
Deferasirox derivatives, such as ExPh and ExBT, are designed to chelate iron and inhibit antibiotic-resistant bacteria like MRSA and VRE. They exhibit unique fluorescent properties for bacterial imaging, offering both therapeutic and diagnostic capabilities.
Background
Antibiotic resistance is a growing public health concern, driven by the rapid evolution...
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Nanoparticle technology for targeted therapeutic and diagnostic delivery
The invention involves nanoparticles for targeted delivery of therapeutic and diagnostic agents. These nanoparticles accumulate in specific tissues, disintegrate upon stimuli, and release active agents, enhancing treatment specificity and efficacy while minimizing systemic effects.
Background
Nanoparticles have their potential to revolutionize drug...
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One and done: A variant-proof coronavirus vaccine
Background/problem
Coronaviruses, including SARS-CoV-2, caused the COVID-19 pandemic of plague-like infectiousness with >770 M cases and 6.9M deaths worldwide. Vaccination provided protection against severe disease progression, hospitalization, and mortality. However, current vaccine technology is in an arms race against the continual evolution...
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First-in-class blood-based diagnostic panel for depression and suicide risk
Background
The instinct to stay alive and maintain well-being is fundamental to all of us, yet nearly a million lives are lost to suicide each year around the world, presenting a significant public health challenge. Despite ongoing efforts, effectively identifying the risk and preventing suicide remains a complex issue. Biologically, suicide often...
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Patient-specific prostate cancer progression prediction model to inform personalized treatment
Problem
Prostate cancer is a significant health problem worldwide, and there is a vital need for accurate predictive models of disease progression to aid in effective treatment planning. Current models are largely statistical, based on a population of patients, and neglect the patient’s unique attributes. There is a significant need for more...
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Sono-optogenetics: A non-invasive optogenetic platform
Problem
Optogenetics is the light-dependent control of genetically modified neurons. Neuronal cells that express microbial opsins can transport ions in a light-gated process. Optogenetics has been used to treat disorders including vision loss in humans. Animal studies indicate that optogenetic therapies have applications in neurological disorders including...
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Treatment of manganese toxicity and manganese-induced Parkinsonism
Problem
Parkinsonian disorders are the second most common neurodegenerative disease in the United States, with no definitive treatment option available. Exposure to the metal manganese has been shown to be a major cause of parkinsonism.
Solution
Dr. Somshuvra Mukhopadhyay and his team have developed a pharmaceutical method for the management of manganese-induced...
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