Recognitive hydrogel technology for precise molecular detection

Background

The field of chemical sensor technology has long sought methods to accurately detect and measure molecular presence and concentration in various environments. A pervasive challenge has been developing sensors that can selectively recognize specific molecules in complex mixtures. Traditional sensors often struggle with non-specific binding, resulting in false positives and limited selectivity. They may also suffer from signal degradation over time or under changing environmental conditions, impairing their reliability and long-term usability.

Technology description

Recognitive hydrogels leveraging molecularly imprinted polymers (MIPs) feature bespoke binding cavities attuned to specific triggering molecules, integrated with conductive polymers for enhanced functionality. These hydrogels form the basis of sensors that utilize an impedance sensing component to monitor the presence of the target molecule precisely and in real-time. What sets this technology apart is the fusion of MIPs with conduc­tive polymers, allowing for a significant improvement in signal trans­duction upon binding of the target molecule. Combined with impedance sensing, this design ensures a highly sensitive and selective response, distinguishing it from traditional sensing mechanisms that may lack specificity or sensitivity.

Benefits

  • High specificity for target molecules
  • Enhanced sensitivity through impedance detection
  • Real-time analysis capabilities
  • Long-term stability and reliability in various conditions
  • Potential for miniaturization and integration into portable devices

Commercial applications

  • Environmental pollutant monitoring
  • Medical diagnostics, such as detecting biomarkers in bodily fluids
  • Chemical process control in industrial settings
  • Food and beverage safety and quality control
  • Drug discovery and pharmaceutical quality assurance

Opportunity

The University of Texas at Austin is seeking an industry partner to license this technology.