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pH-responsive hydrogel technology for enhanced oral delivery of therapeutic proteins
Improved hydrogel copolymers, made from itaconic acid and N-vinylpyrrolidone, enable oral delivery of therapeutic proteins by protecting them in the stomach and releasing them in the intestine. This enhances protein bioavailability and pharmacokinetics.
Background
Oral delivery of therapeutic proteins presents significant challenges due to the...
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Nanoscale, pH-responsive polycationic networks for targeted delivery of anionic biologic therapeutics
This technology involves nanoscale, pH-responsive polycationic hydrogels for delivering anionic biologic therapeutics like siRNA. These hydrogels, made from crosslinked copolymers, trap therapeutics at physiological pH and release them in lower pH environments, enhancing biocompatibility and targeted delivery.
Background
The delivery of small...
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Adaptive soft elastomeric material system with programmable functions inspired by venous valves
Programmable soft elastomeric materials, inspired by mammalian venous valves, alter their properties to perform life-like functions including motion, energy storage, logic operations, and signal filtering.
Background
Materials science and bioengineering aim to replicate the fundamental processes of living organisms through artificial material systems....
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Metabolic engineering of Yarrowia lipolytica for high‑level polyketide production
Background
The field of biotechnology has seen significant advancements in the use of genetically modified organisms to produce valuable compounds. Polyketides, a diverse class of secondary metabolites, are of particular interest due to their wide-ranging applications in pharmaceuticals, bioactive compounds, and renewable chemicals. Traditional methods...
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Metabolic control over organometallic catalysts using electroactive bacteria
Background
Dr. Benjamin Keith Keitz and his team have developed a new controlled polymerization methodology using an electroactive bacterium to synthesize responsive materials. Dr. Keitz is an Assistant Professor in the Department of Chemical Engineering at UT Austin. His primary research area focuses on using chemical and biological synthesis techniques...
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Genetically encoded protein-based fluorescent biosensor for adenosine diphosphate ribose
Background
Adenosine diphosphate ribose (ADPR) is a biologically important molecule that is known to regulate oxidative stress, calcium homeostasis, and mitochondrial function. Very little is known about ADPR signaling because it is a fast and transient process. Our innovation addresses this challenge by streamlining the development of fluorescent...
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Biomimetic high-strength bone implant polymer material
Problem
Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
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Bacterial reagents: stable, low-cost, readily available reagents with no purification requirements
Problem Most molecular biology techniques commonly used in research, biotechnology, healthcare, and education rely heavily on purified functional protein reagents. However, purification of these protein reagents requires substantial investment of time, expertise, equipment, and infrastructure. As a result, this significantly limits the availability...
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Fibrosis-free microfluidic meshwork implant for treating glaucoma
BackgroundGlaucoma is the leading cause of irreversible blindness in the world and affects almost three million people in the United States alone. The primary treatment option is to reduce the intraocular pressure (IOP) caused by fluid buildup in the affected eye, which is frequently accomplished by surgery to create an outflow of the accumulated fluid....
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