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Recognitive hydrogel technology for precise molecular detection
Background
The field of chemical sensor technology has long sought methods to accurately detect and measure molecular presence and concentration in various environments. A pervasive challenge has been developing sensors that can selectively recognize specific molecules in complex mixtures. Traditional sensors often struggle with non-specific binding,...
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Method for detecting antibodies to folic acid
Background
Folate, an essential B-vitamin, is crucial for a variety of health-related functions. The recognition that too few women obtained sufficient folate levels from their diet and knowing that a folate deficiency put embryos at risk for serious birth defects led to mandatory fortification of certain foods to prevent deficiencies. Such preventive...
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Rapid, multi-targeted, modular virus sensing platform based on graphene field-effect sensing
Background
The SARS-CoV-2 pandemic underscored the necessity for rapid and precise detection of viruses that share similar symptoms, leading to a strain on healthcare systems. Identifying specific pathogens such as influenza alongside COVID‑19 is crucial for tailored treatment plans.
Technology overview
A novel technology based on liquid-gated graphene...
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First-in-class blood-based diagnostic panel for depression and suicide risk
Background
The instinct to stay alive and maintain well-being is fundamental to all of us, yet nearly a million lives are lost to suicide each year around the world, presenting a significant public health challenge. Despite ongoing efforts, effectively identifying the risk and preventing suicide remains a complex issue. Biologically, suicide often...
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Knitted strain sensor for pharyngeal rehabilitation
Problem
Dysphagia, or swallowing dysfunction, affects 9.5 million people in the United States. Dysphagia poses significant risks including malnutrition, dehydration, aspiration pneumonia, and death. Dysphagia is associated with diseases including stroke, muscular dystrophy, and throat cancer. The impact of dysphagia extends beyond physical discomfort,...
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Wireless e-tattoo for ambulatory monitoring of cardiovascular health
Background
Cardiovascular diseases (CVD) are the leading cause of death in the United States and the world, with hundreds of billions of dollars spent on treating CVD. Heart diseases kill 700,000 people in the United States and nearly four million in the world every year. Early-stage discovery of CVD is critical to treatment preventing fatalities and...
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Full-length excised intron RNA sequencing and analysis for disease diagnosis
Problem
RNA molecules that are newly transcribed from the corresponding DNA sequence contain intron and exon sequences. Introns are removed by a process called RNA splicing, where the introns are removed and the exons are ligated to form the mature messenger RNA (mRNA) and full-length excised intron RNAs (FLEXIRs). The majority of FLEXIRs and the genes...
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An engineered methyltransferase enzyme for improved production of benzylisoquinoline alkaloids
Background
Tetrahydropapaverine (THP) and papaverine are naturally occurring plant alkaloids that are commercially important. THP is a precursor of the drugs atracurium and cisatracurium, used as muscle relaxants. Papaverine is used as an antispasmodic. These clinically useful molecules may be synthesized using traditional organic synthesis methods...
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New MRI acquisition and post-processing technique for improved breast cancer diagnosis
New computational imaging platform can improve patient-specific characterization of breast cancerProblemClinicians rely on imaging to direct the path of treatment for breast cancer. The current standards for vascular imaging, MRI and CT, can miss valuable information. Fortunately, there has been a wave of technical progress with digital health technologies....
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At-home diagnostic system for managing heart failure
Background
In the past year, we have seen widespread adoption of at-home and drive-through diagnosis. Dispersion of the first line of healthcare is creating a massive opportunity to lower healthcare costs and improve disease management for millions of patients. With more than 5 million patients in the United States and 11 million physician visits each...
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