Search results for life+sciences+%3e+therapeutics+%3e+drug+discovery

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Yeast-based screening platform for rapid identification of GPCR agonists

This invention is a yeast-based screening platform that uses tethered peptide libraries to identify human GPCR agonists quickly and cost-effectively, yielding receptor-specific ligands and valuable insights into GPCR drug discovery. Background The field of receptor pharmacology and drug discovery continues to seek improved methods for reliably identifying...

Inventor(s): Andrew Ellington, Colleen Mulvihill, Jimmy Gollihar, Elizabeth Gardner, Edward Marcotte | Published: 3/4/2025

Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Therapeutics > Drug discovery

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Advanced hot melt extrusion (HME) technology with reduced decomposition

The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...

Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang | Published: 9/10/2024

Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials

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