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Antibody compositions for improving detection and treatment of Bacillus anthracis infections
This technology uses specially designed antibodies with enhanced ability to detect or treat Bacillus anthracis infections, improving both diagnosis and therapy for anthrax.
Background
Bacillus anthracis, the causative agent of anthrax, is a highly virulent bacterium that poses significant threats to both public health and national security. Anthrax...
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Dual-target antibody toolkit for overcoming resistance in anti-angiogenic cancer therapy
Background
Angiogenesis is a fundamental process in cancer progression, enabling tumors to grow and metastasize by forming new blood vessels. Vascular endothelial growth factor A (VEGFA) is a central driver of this process and a primary target for existing anti-angiogenic therapies.
However, clinical resistance often develops through the compensatory...
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Antibody and T-cell receptor sequencing for identifying cancer-specific immune receptors
This tech identifies cancer-specific antibodies and T-cell receptors by sequencing mRNA from immune cells in a patient’s tumor-draining lymph nodes and comparing the sequences with the patient’s antibody polypeptide data.
Background
Cancer immunotherapy has emerged as a promising approach to treating various types of cancers. This field...
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Engineered antibodies for enhanced immune response
Recombinant antibodies with engineered human IgG1 Fc domains have been developed to resist viral Fc receptor capture, enhancing immune targeting of virus-infected cells. These antibodies maintain normal host receptor affinity, potentially improving therapeutic outcomes against HCMV and related viruses.
Background
Human cytomegalovirus (HCMV) infection...
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Monoclonal antibodies for the conserved feature of the coronavirus spike protein
The invention describes monoclonal antibodies targeting conserved epitopes on the S2 domain of coronavirus spike proteins, potentially useful for preventing or treating infections by inhibiting viral entry. These antibodies could aid in therapeutic formulations against coronaviruses like SARS-CoV-2, SARS-CoV, and MERS-CoV.
Background
The emergence...
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Methodology for high-throughput sequencing of paired antibody transcripts from B cells
The technology enables rapid and accurate sequencing of paired VH and VL antibody transcripts from single antigen-specific B cells. It involves isolating B cells, capturing their mRNA and antibodies, forming complexes with affinity agents, purifying these complexes, and performing RT-PCR to generate and sequence cDNA, facilitating various immunological...
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Affinity measurement and sequencing of T cell receptor
The technology enables the measurement of T cell receptor (TCR) affinity and sequencing of antigen-specific T cells using a micropipette adhesion assay and single-cell paired TCRα/TCRβ sequencing. The method isolates antigen-specific T cells, measures TCR affinity, and determines TCR sequences for applications in immunotherapy and monitoring...
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Dual-target defense: bispecific antibodies revolutionize pertussis toxin neutralization
Bispecific antibodies target two epitopes on the pertussis toxin protein, enhancing toxin neutralization. Engineered using “knobs-into-holes” technology, they form stable heterodimers, offering similar efficacy to antibody mixtures but with streamlined manufacturing and regulatory benefits.
Background
Pertussis, or whooping cough,...
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Treating respiratory diseases and whooping cough
This technology involves compositions and methods for treating respiratory diseases like whooping cough and includes immunization techniques.
Background
The field of respiratory disease treatment and immunization is important due to the significant health burden posed by conditions such as whooping cough. Whooping cough, or pertussis, is a highly...
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High-throughput sequencing technology for T-cell receptor specificity
TetTCR-seq is a method for high-throughput pairing of T cell receptor (TCR) sequences with their specific antigens using DNA-barcoded pMHC tetramers, enabling rapid, cost-effective immune profiling, disease diagnosis, and therapeutic development.
Background
The identification of antigen-specific T-cell receptors (TCRs) is crucial for understanding...
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