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Wearable ultrasound device for long-term neuromodulation
This wearable ultrasound device uses a miniaturized transducer and bio-adhesive hydrogel to non-invasively stimulate the brain for long durations, potentially treating neurological disorders.
Background
Transcranial focused ultrasound (tFUS) has emerged as a promising non-invasive technique for neuromodulation, offering advantages over existing methods...
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Molecularly imprinted polymers for high-specificity template molecule recognition
Molecularly imprinted polymers are created using calcium alginate microcapsules that can specifically recognize and bind template molecules like proteins. These biocompatible microcapsules are useful in medical diagnostics and food industry detection and can be reused after washing.
Background
Molecularly imprinted polymers (MIPs) have garnered significant...
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Hydrogel matrix technology for accelerating tissue-engineered dermal and vascular formation
A tissue-engineered dermal equivalent uses a hydrogel matrix with two distinct layers and mesenchymal stem cells (MSCs). One layer promotes blood vessel cell formation, while the other encourages dermal fibroblast development, facilitating vascular and dermal tissue creation from a single stem cell source.
Background
Severe skin injuries, such as...
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Highly porous recognitive polymer systems for controlled release of active agents
The invention is a porous, recognitive polymeric hydrogel system that releases active agents, like insulin, in response to specific triggers such as glucose. It uses methacrylic acid and sodium chloride to create a matrix that swells, cracks, or dissolves under low water or humidity conditions.
Background
The challenge of delivering active agents...
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Sustainable high molecular weight copolymers using the Vandenberg catalyst
This technology creates high molecular weight copolymers from lactones and epoxides using the Vandenberg catalyst. The process produces versatile, biodegradable materials with unique thermal properties and potential applications in environmental and biomedical fields.
Background
Copolymerization of lactones and epoxides is a crucial area of research...
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Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability.
Background
HME is a widely used technique in the pharmaceutical...
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Nanoscale, pH-responsive polycationic networks for targeted delivery of anionic biologic therapeutics
This technology involves nanoscale, pH-responsive polycationic hydrogels for delivering anionic biologic therapeutics like siRNA. These hydrogels, made from crosslinked copolymers, trap therapeutics at physiological pH and release them in lower pH environments, enhancing biocompatibility and targeted delivery.
Background
The delivery of small...
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Precision bioprinting robot for bio-ink deposition and analysis
A bioprinting robotic system uses a robotic arm with a bioprinting tool to deposit bio-ink for tissue repair. It includes sensors, a 3D camera, and a head-mounted display for precise control and real-time feedback, ensuring accurate and safe bioprinting.
Background
The field of bioprinting technology is a subset of tissue engineering that utilizes...
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Metabolic engineering of Yarrowia lipolytica for high‑level polyketide production
Background
The field of biotechnology has seen significant advancements in the use of genetically modified organisms to produce valuable compounds. Polyketides, a diverse class of secondary metabolites, are of particular interest due to their wide-ranging applications in pharmaceuticals, bioactive compounds, and renewable chemicals. Traditional methods...
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Ultrasound-programmable nanoparticles for targeted drug release
Background/problem
Ideally, a drug meant to accurately target specific tissues or cells involved in a disease will do so and achieve an optimal dose and treatment duration. These will yield the intended cellular and physiological response without undue off-target and side effects. And yet, we live with the reality and risks of side effects. Novel...
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