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Novel compounds as diagnostic and therapeutic agents for CNS diseases and cancer
Piperazinyl norbenzomorphan compounds for modulating sigma 2 receptors in therapy and diagnostics
This technology introduces a new class of compounds that selectively target sigma-2 receptors, offering potential treatments for cancer, neurological, psychiatric, cardiovascular, and inflammatory diseases, as well as cognitive enhancement and diagnostic...
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Inhalable Dry Powder Biosensor Platform for Noninvasive Detection and Monitoring of Pulmonary Disease Activity
This technology uses inhalable dry powder biosensors that detect lung disease by releasing a reporter molecule in response to disease-related enzymes; the reporter is then measured in urine, enabling fast, noninvasive diagnosis and monitoring of lung conditions.
Background
Chronic respiratory diseases (CRDs) and lung cancer represent significant global...
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New approach to fight hormone dependent cancers using covalent inhibition of AKR1C3
Background
Aldo-keto reductase family 1 member C3 (AKR1C3) is a key enzyme involved in the metabolism of steroid hormones and prostaglandins, playing a central role in the progression of hormone-dependent cancers such as prostate, breast, and endometrial cancers, as well as in certain inflammatory diseases. Given its pivotal function in these pathologies,...
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PhAzE chemistry for selective covalent modification of protein tyrosine and lysine residues
PhAzE chemistry uses cell-permeable phospho-triazole reagents to covalently bond tyrosine and lysine residues in proteins, mimicking natural phosphorylation with low toxicity and tunable reactivity, enabling chiral probe design and potential RNA targeting.
Background
Covalent chemistry has become a cornerstone of modern chemical biology and drug discovery,...
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Intranasal Levothyroxine Formulation
Eliminates variable oral bioavailability: Intranasal levothyroxine powder delivers 2x mucosal permeation.
This technology is a stable, intranasal dry powder formulation of levothyroxine free acid designed to improve absorption and avoid degradation, offering a more reliable alternative to oral thyroid hormone therapy for hypothyroidism.
Background
Hypothyroidism...
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Simvastatin In-Situ Gel
Thermoresponsive nanoscale intranasal delivery system for enhancing direct nose-to-brain drug delivery
This technology is an intranasal gel spray that uses nanoscale simvastatin particles and mucoadhesive, thermoresponsive gel to improve brain drug delivery, increase nasal retention, and bypass first-pass metabolism for better treatment of neurological...
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Inhaled dry powders of nucleic acid-polymer polyplexes
Eliminates mRNA cold chain delivering inhalable powders with 71% aerosol efficiency.
This technology creates stable, inhalable dry powders of mRNA-polymer complexes using thin-film freeze-drying, enabling room-temperature storage and efficient pulmonary delivery of RNA therapeutics, including CRISPR, for treating lung diseases without the need for...
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Thin-film freeze-dried antibiotic powders for fixed-dose pulmonary delivery
Background
Pulmonary diseases such as nontuberculous mycobacterial infections and chronic obstructive pulmonary disease (COPD) remain major global health challenges, often requiring long-term antibiotic therapy delivered directly to the lungs to achieve effective pathogen clearance.
Inhaled drug delivery provides a promising approach to increase local...
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Sulfonyl-triazole activators for cell-selective glycolysis enhancement in cancer and Parkinson’s disease
Background
Cellular metabolism is a central regulator of immune cell function and neuronal survival, making it a promising therapeutic target in both cancer and neurodegenerative disease. In solid tumors, tumor-infiltrating lymphocytes (TILs) frequently succumb to metabolic exhaustion due to the nutrient-depleted and immunosuppressive microenvironment,...
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Spray-dried RNA-lipid nanoparticle dry powder technology for stable and inhalable delivery of therapeutics
Background
Messenger RNA (mRNA) therapeutics have rapidly emerged as a transformative method for vaccination and gene therapy. However, the field faces significant hurdles related to the instability of mRNA molecules, which are highly susceptible to enzymatic degradation. Lipid nanoparticles (LNPs) have become the delivery vehicle of choice, shielding...
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