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Multilayered drug delivery implants for localized brain tumor therapy
Background
As treatment strategies evolve for brain tumors, especially post-surgical resection, localized therapy is emerging as a promising alternative to systemic drug delivery. The blood-brain barrier, along with the sensitive anatomy of the brain, makes it difficult to achieve effective therapeutic concentrations using traditional methods without...
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Engineered SGPL1 enzymes for selective extracellular S1P depletion in cancer immunotherapy
Background
The sphingosine-1-phosphate (S1P) signaling axis plays a pivotal role in regulating immune cell trafficking, particularly in the context of cancer immunotherapy. S1P gradients between tumor-draining lymph nodes and the tumor microenvironment govern lymphocyte migration, with elevated extracellular S1P concentrations leading to...
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SMART 3D-printed proliposomes for stable, targeted drug delivery
Background
In the realm of drug delivery, particularly for cancer therapeutics, there is a growing demand for robust nanocarrier systems that offer improved targeting, extended shelf-life, and consistent efficacy. Liposomes have historically served as biocompatible delivery vehicles; however, they often suffer from formulation instability and limited...
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Controlled synthesis of poly(acetamidosaccharide) for sustainable and versatile materials
A new sustainable polymer, poly(acetamidosaccharide), is created through a simple two-step process. Serving as a sustainable cellulose acetate alternative, it mitigates microplastic pollution and offers customizable properties suitable for textiles, coatings, biotechnology, and food stabilization.
Background
Polymer science is integral to numerous...
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Small molecule compounds for REST degradation in glioblastoma cells
Scientists developed a new drug, GR-28, that inhibits a protein called SCP1. This leads to the degradation of another protein, REST, which promotes the growth of brain tumor cells. Combining GR-28 with a lipid metabolism inhibitor shows synergistic effects in killing tumor cells.
Background
Glioblastoma (GBM) is a highly aggressive and fatal brain...
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Specialized storage technology for preserving axonal viability
A specialized calcium-free solution preserves peripheral nerve axons for up to nine days at low temperatures, enhancing nerve graft viability for effective repair of injuries using polyethylene glycol fusion, promoting rapid sensory and motor recovery.
Background
Peripheral nerve injuries (PNIs) often result in segmental-loss defects, leading to immediate...
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Advanced nanoparticle delivery system for targeted pulmonary administration of therapeutic nucleic acids
Lipid nanoparticles (LNPs) are designed for delivering RNA to lung tissues via inhalation. Composed of ionizable lipids, phospholipids, PEG-lipids, and cholesterol, they encapsulate RNA for therapeutic or immunological purposes, maintaining stability during nebulization.
Background
Gene therapy and editing hold significant promise for treating genetic...
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Multifunctional iron chelators to combat antibiotic resistance and enable bacterial imaging
Deferasirox derivatives, such as ExPh and ExBT, are designed to chelate iron and inhibit antibiotic-resistant bacteria like MRSA and VRE. They exhibit unique fluorescent properties for bacterial imaging, offering both therapeutic and diagnostic capabilities.
Background
Antibiotic resistance is a growing public health concern, driven by the rapid evolution...
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Biocompatible proteoliposome technology for enhanced wound healing and reduced inflammation in diabetic patients
Syndesomes—lipid vesicles with embedded syndecan-4 and PDGF-BB—enhance wound healing by promoting cellular activities, reducing inflammation, and improving tissue regeneration. They are particularly effective in diabetic and obese models, supporting re-epithelialization and angiogenesis.
Background
Chronic non-healing wounds, particularly...
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pH-sensitive hydrogel technology for enhanced oral delivery of high molecular weight therapeutic proteins
This invention describes a pH-sensitive hydrogel for oral delivery of therapeutic proteins like factor VIII or IX, used in hemophilia treatment. It protects proteins in the stomach and releases them in the intestine, enhancing bioavailability.
Background
Delivering therapeutic proteins orally presents significant challenges due to the body's natural...
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