Search results for Life+sciences+%3e+Therapeutics+%3e+Drug+discovery

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Sulfonyl-triazole activators for cell-selective glycolysis enhancement in cancer and Parkinson’s disease

Background Cellular metabolism is a central regulator of immune cell function and neuronal survival, making it a promising therapeutic target in both cancer and neurodegenerative disease. In solid tumors, tumor-infiltrating lymphocytes (TILs) frequently succumb to metabolic exhaustion due to the nutrient-depleted and immunosuppressive microenvironment,...

Inventor(s): Ku-Lung Hsu, Xiaoding Jiang, Xiaolu Cambronne | Published: 1/27/2026

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug discovery

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Microneedle array coating technology for enhanced stability and targeted delivery of mRNA and biologics

A microneedle-based system uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...

Inventor(s): Zhengrong Cui, Michael Sandoval, Robert Williams, Drew Weissman, Qin Li | Published: 1/27/2026

Category(s): Life sciences > Therapeutics > Drug discovery

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Advanced hot melt extrusion (HME) technology with reduced decomposition

The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...

Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang | Published: 1/13/2026

Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials

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