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Fluorescence lifetime imaging for retinal function assessment
This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration.
Background
Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...
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In-beam PET for FLASH proton therapy monitoring
This technology uses PET imaging to visualize and measure radiation doses from a FLASH proton beam, a new type of radiation therapy, in real-time.
Background
Proton therapy, a cornerstone of radiation oncology, holds immense potential for precise cancer treatment. While advances in accelerator technology and treatment planning have been significant,...
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Wearable tongue tracker for silent speech interfaces
MagTrack is a lightweight, wearable device that utilizes magnetic fields to track tongue movements, enabling silent speech recognition and other applications like speech therapy.
Background
Silent speech interfaces (SSIs) aim to restore communication for individuals who have lost their voice but retain the ability to articulate, such as those who...
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Nanotech for enhanced diagnostic imaging and therapeutic applications
Liposomal J-aggregates of Indocyanine Green are nanoparticles designed for enhanced photoacoustic imaging and photothermal therapy. They offer improved photostability, longer circulation, and efficient heating, hence their promise for diagnostic and therapeutic applications.
Background
Photoacoustic imaging (PAI) is a promising non-invasive clinical...
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High-speed laser scanning and microfluidic device system for automated 3D imaging and specimen manipulation
The high-speed laser scanning microscopy platform enables rapid, automated 3D imaging of biological specimens, offering flexible control over imaging parameters, large field-of-view, and high-resolution imaging, ideal for studying dynamic processes in living organisms.
Background
Laser scanning systems, particularly in the field of microscopy, have...
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Predicting breast cancer response to therapy with MRI and modeling
Background/problem
Neoadjuvant therapy (NAT) for cancer treatment is currently based on generalized population-based data such as receptor status, tumor grade, body surface area, and genetic markers. This approach is inherently limited, as it does not account for the unique spatial and physiological characteristics of individual tumors. Consequently,...
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Inflatable sensor for topographic mapping of internal cavities
The technology involves a flexible, inflatable tactile sensor that attaches to medical or industrial tools, providing high-resolution texture and stiffness mapping. It enhances diagnostics by offering detailed surface analysis, useful in medical procedures like colonoscopies and industrial inspections like oil and gas pipelines.
Background
The field...
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Integrated laser system for precision imaging and surgical manipulation of biological tissue
The system uses an ultra-fast pulsed laser, optical fibers, and lenses for precise surgical manipulation and imaging of biological tissues. It combines laser surgery with imaging techniques like multiphoton microscopy, confocal reflectance, fluorescence, and optical coherence tomography for enhanced medical diagnostics and treatment.
Background
Precision...
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Advanced PAI contrast agents for early cancer detection
This technology involves creating biodegradable nanoparticles (nanocapsules) that selectively target diseased cells, such as cancer cells, for imaging and treatment. These nanocapsules contain indocyanine green (ICG) dye aggregates, which are stable and offer high contrast when using near-infrared photoacoustic imaging, enabling the detection...
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2-photon endoscopic fluorescence probe for advanced medical imaging
Background/problem
Existing approaches to tissue imaging, particularly for early cancer detection, face several significant challenges. Techniques such as MRI and PET provide functional information but lack the cellular-level resolution needed for early diagnosis and involve contrast agents and radiation exposure. Two-photon (2P) fluorescence imaging...
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