Integrated laser system for precision imaging and surgical manipulation of biological tissue

The system uses an ultra-fast pulsed laser, optical fibers, and lenses for precise surgical manipulation and imaging of biological tissues. It combines laser surgery with imaging techniques like multiphoton microscopy, confocal reflectance, fluorescence, and optical coherence tomography for enhanced medical diagnostics and treatment.

Background

Precision imaging and surgical manipulation of biological tissue are critical for improving medical treatment outcomes, yet existing technologies face significant challenges. Traditional imaging methods often lack the resolution and real-time capabilities needed for precise surgical interventions. Conventional surgical tools, while effective for many procedures, can lead to collateral damage to surrounding healthy tissues, especially in delicate or densely packed cellular environments. Additionally, the integration of imaging and surgical functionalities into a single device remains complex, often requiring bulky equipment that is not conducive to minimally invasive procedures. The need for high precision, minimal invasiveness, and real-time feedback during surgery necessitates advanced solutions that can seamlessly combine high-resolution imaging with targeted surgical manipulation.

Technology description

The system described is a sophisticated medical technology designed for both imaging and surgical manipulation of biological tissue. It utilizes an ultra-fast pulsed surgical laser light source, which is transmitted through an optical delivery fiber to an objective lens, targeting a specific region for surgical intervention. The system also includes an imaging light source that directs light through relay lenses to the same objective lens for precise imaging of the tissue. A scanning device, either microelectromechanical or piezoelectric, manages the light for both imaging and surgical purposes. Additionally, a photodetector captures the light from the targeted region, and a processing device generates images from this data. This setup allows for high-precision surgical manipulation and detailed imaging, making it highly applicable in medical diagnostics and treatments.

This technology stands out due to its integration of ultra-fast laser pulses for surgical precision and advanced imaging capabilities within a single system. The use of an air-core photonic crystal fiber for light delivery ensures minimal dispersion and high-intensity laser pulses, crucial for precise tissue ablation without damaging surrounding areas. The microelectromechanical scanning device provides accurate control over the laser and imaging light, enhancing the system’s ability to target and treat specific tissues.

Furthermore, the combination of imaging and surgical functionalities in one device streamlines medical procedures, reducing the need for multiple instruments and allowing for real-time diagnostics and treatment. This dual capability significantly improves the efficiency and effectiveness of medical interventions, particularly in delicate and complex surgical environments.