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DNAzymes for on-site portable detection of lithium and other metal ions
Portable DNAzyme-based sensor system for on-site lithium quantification in mining and battery recycling
A portable fluorescent DNAzyme sensor detects lithium on-site across brine and hard rock mining and battery recycling, using temperature-optimized binding arms and sample-specific prep to distinguish Li⁺ at 10 ppm amid interfering metals, enabling...
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A platform of DNA-functionalized protein nanostructures for enhancing and delivering catalytic enzyme activity
This technology boosts the catalytic activity of heme-containing proteins by densely attaching short DNA strands, creating stable, biocompatible constructs that autonomously enter cells, enabling advanced therapeutic, antimicrobial, and biosensing applications without genetic modification or toxic delivery agents.
Background
Enzymes, particularly...
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Biological Expression Platform for Producing and Engineering Electrically Conductive Protein Nanowires and Bioelectronic Materials
This technology uses engineered Shewanella oneidensis bacteria to rapidly produce highly conductive protein nanowires for sustainable energy, bioelectronics, and sensor applications, offering a scalable, cost-effective, and eco-friendly alternative to synthetic conductive materials.
Background
The field of bioelectronics and sustainable energy harvesting...
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Nucleopeptide hybrid hydrogels
Eliminates Xenogeneic Matrix Variability: Synthetic Hydrogel Delivers Reproducible 3D hiPSC Culture
This technology is a customizable, fully synthetic hydrogel made from self-assembling nucleopeptides, designed to mimic the natural cell environment, support stem cell growth, deliver growth factors and nucleic acids, and replace animal-derived cell...
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A multiplexed CRISPR genome editing platform for simultaneous gene disruption in neurons
SPADA is a CRISPR-based genome editing system that uses engineered viruses to efficiently and specifically disrupt multiple genes in targeted brain cells, enabling precise modeling of complex genetic brain disorders in animals.
Background
The field of neurogenetics relies heavily on genome editing to understand the mechanisms of complex psychiatric...
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Engineered yeast strains for enhanced conversion of xylose to ethanol from lignocellulosic biomass
This technology uses genetically engineered yeast with an improved xylose isomerase enzyme to efficiently convert xylose from plant biomass into ethanol, greatly boosting biofuel production rates and yields for sustainable energy applications.
Background
Lignocellulosic biomass, such as agricultural residues and woody materials, represents a vast...
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Liquid-phase gas nanotransducers as an ultrasound actuator and imaging reporter
Background
Ultrasound imaging and actuation technologies play a critical role in modern medicine, however applications rely heavily on the use of gas-filled agents, such as microbubbles and gas vesicles, which enhance ultrasound contrast and facilitate mechanical effects in biological tissues. The demand for improved imaging resolution, deeper tissue...
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Non-invasive sono-optogenetic platform for deep brain neural modulation
Background
Neuromodulation technologies such as deep brain stimulation and optogenetics have transformed the treatment of neurological disorders by enabling targeted control of dysfunctional neural circuits, yet their clinical adoption is limited by invasive surgical requirements, off-target effects, poor penetration depth, and lack of cell-type specificity....
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Engineered prodrug with tumor-selective delivery for targeted glycolysis inhibition.
Engineered prodrug with tumor-selective delivery for targeted glycolysis inhibition
A conjugate of 2-deoxy-D-glucose and a fatty acid forms albumin-binding nanoparticles that enter cancer cells via glucose and fatty acid transporters, inhibit glycolysis, and induce tumor-selective cell death with enhanced potency and targeting.
Background
The...
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DNAzyme-based biosensor technology for selective and real-time detection of potassium ions in biological systems
Background
The ability to monitor potassium ion (K+) dynamics is of critical importance, particularly in the context of cancer research and neurobiology. Potassium ions play a fundamental role in maintaining cellular homeostasis, regulating membrane potential, and influencing processes such as cell proliferation, apoptosis, and immune responses. Disruptions...
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