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DNAzyme-based biosensor technology for selective and real-time detection of potassium ions in biological systems
Background
The ability to monitor potassium ion (K+) dynamics is of critical importance, particularly in the context of cancer research and neurobiology. Potassium ions play a fundamental role in maintaining cellular homeostasis, regulating membrane potential, and influencing processes such as cell proliferation, apoptosis, and immune responses. Disruptions...
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Precision-crafted membranes for enhanced separation efficiency
This technology enables fast, scalable production of durable biomimetic membranes by co-depositing polymers and nanosheets with embedded channels, then covalently crosslinking them, creating high-performance filters for water purification and molecular separations with enhanced permeability and selectivity.
Background
Membrane-based separation technologies...
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3D-printed, patient-specific external breast prostheses with enhanced comfort and thermal performance
Background
External breast prostheses (EBPs) play a vital role in post-mastectomy care, with approximately 80 percent of U.S. mastectomy patients relying on them to restore symmetry, improve self-image, and enhance quality of life. Despite their widespread use, conventional silicone-based prostheses often fail to meet patients' comfort and personalization...
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Detergent-induced crystallization of protein-polymer nanosheets for rapid membrane production
Background
Biomimetic membranes offer transformative potential in areas such as desalination, molecular separations, and sustainable resource recovery. These membranes depend on the integration of functional membrane proteins within polymeric nanosheets. However, the widespread adoption of these technologies has been limited by slow, inefficient, and...
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Tunable dual-network viscoelastic hydrogels for tissue engineering and cell modeling
Background
Advances in tissue engineering and regenerative medicine continue to emphasize the importance of recreating physiologically relevant mechanical environments for in vitro studies. Cellular behavior, tissue regeneration, and drug response are all significantly influenced by the viscoelasticity of the surrounding matrix. While native tissues...
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Amphiphilic glycopolymer nanomaterials for pH‐responsive heavy metal and rare earth ion removal
A novel, recyclable polymer technology uses ring‐opening metathesis to create nanoscale, pH-responsive glycopolymers with glucuronic acid side chains that efficiently capture heavy metals and selectively bind rare earth elements from water.
Background
The need for advanced metal ion separation technologies has grown due to increasing environmental...
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DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies.
Background
Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
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DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s.
Background
Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
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Wearable ultrasound device for long-term neuromodulation
This wearable ultrasound device uses a miniaturized transducer and bio-adhesive hydrogel to non-invasively stimulate the brain for long durations, potentially treating neurological disorders.
Background
Transcranial focused ultrasound (tFUS) has emerged as a promising non-invasive technique for neuromodulation, offering advantages over existing methods...
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Molecularly imprinted polymers for high-specificity template molecule recognition
Molecularly imprinted polymers are created using calcium alginate microcapsules that can specifically recognize and bind template molecules like proteins. These biocompatible microcapsules are useful in medical diagnostics and food industry detection and can be reused after washing.
Background
Molecularly imprinted polymers (MIPs) have garnered significant...
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