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Liquid-phase gas nanotransducers as an ultrasound actuator and imaging reporter
Background
Ultrasound imaging and actuation technologies play a critical role in modern medicine, however applications rely heavily on the use of gas-filled agents, such as microbubbles and gas vesicles, which enhance ultrasound contrast and facilitate mechanical effects in biological tissues. The demand for improved imaging resolution, deeper tissue...
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Non-invasive sono-optogenetic platform for deep brain neural modulation
Background
Neuromodulation technologies such as deep brain stimulation and optogenetics have transformed the treatment of neurological disorders by enabling targeted control of dysfunctional neural circuits, yet their clinical adoption is limited by invasive surgical requirements, off-target effects, poor penetration depth, and lack of cell-type specificity....
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Engineered prodrug with tumor-selective delivery for targeted glycolysis inhibition.
Engineered prodrug with tumor-selective delivery for targeted glycolysis inhibition
A conjugate of 2-deoxy-D-glucose and a fatty acid forms albumin-binding nanoparticles that enter cancer cells via glucose and fatty acid transporters, inhibit glycolysis, and induce tumor-selective cell death with enhanced potency and targeting.
Background
The...
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DNAzyme-based biosensor technology for selective and real-time detection of potassium ions in biological systems
Background
The ability to monitor potassium ion (K+) dynamics is of critical importance, particularly in the context of cancer research and neurobiology. Potassium ions play a fundamental role in maintaining cellular homeostasis, regulating membrane potential, and influencing processes such as cell proliferation, apoptosis, and immune responses. Disruptions...
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Precision-crafted membranes for enhanced separation efficiency
This technology enables fast, scalable production of durable biomimetic membranes by co-depositing polymers and nanosheets with embedded channels, then covalently crosslinking them, creating high-performance filters for water purification and molecular separations with enhanced permeability and selectivity.
Background
Membrane-based separation technologies...
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3D-printed, patient-specific external breast prostheses with enhanced comfort and thermal performance
Background
External breast prostheses (EBPs) play a vital role in post-mastectomy care, with approximately 80 percent of U.S. mastectomy patients relying on them to restore symmetry, improve self-image, and enhance quality of life. Despite their widespread use, conventional silicone-based prostheses often fail to meet patients' comfort and personalization...
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Detergent-induced crystallization of protein-polymer nanosheets for rapid membrane production
Background
Biomimetic membranes offer transformative potential in areas such as desalination, molecular separations, and sustainable resource recovery. These membranes depend on the integration of functional membrane proteins within polymeric nanosheets. However, the widespread adoption of these technologies has been limited by slow, inefficient, and...
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Tunable dual-network viscoelastic hydrogels for tissue engineering and cell modeling
Background
Advances in tissue engineering and regenerative medicine continue to emphasize the importance of recreating physiologically relevant mechanical environments for in vitro studies. Cellular behavior, tissue regeneration, and drug response are all significantly influenced by the viscoelasticity of the surrounding matrix. While native tissues...
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Amphiphilic glycopolymer nanomaterials for pH‐responsive heavy metal and rare earth ion removal
A novel, recyclable polymer technology uses ring‐opening metathesis to create nanoscale, pH-responsive glycopolymers with glucuronic acid side chains that efficiently capture heavy metals and selectively bind rare earth elements from water.
Background
The need for advanced metal ion separation technologies has grown due to increasing environmental...
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DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies.
Background
Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
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