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Tunable dual-network viscoelastic hydrogels for tissue engineering and cell modeling
Background
Advances in tissue engineering and regenerative medicine continue to emphasize the importance of recreating physiologically relevant mechanical environments for in vitro studies. Cellular behavior, tissue regeneration, and drug response are all significantly influenced by the viscoelasticity of the surrounding matrix. While native tissues...
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Amphiphilic glycopolymer nanomaterials for pH‐responsive heavy metal and rare earth ion removal
A novel, recyclable polymer technology uses ring‐opening metathesis to create nanoscale, pH-responsive glycopolymers with glucuronic acid side chains that efficiently capture heavy metals and selectively bind rare earth elements from water.
Background
The need for advanced metal ion separation technologies has grown due to increasing environmental...
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DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies.
Background
Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
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DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s.
Background
Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
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Wearable ultrasound device for long-term neuromodulation
This wearable ultrasound device uses a miniaturized transducer and bio-adhesive hydrogel to non-invasively stimulate the brain for long durations, potentially treating neurological disorders.
Background
Transcranial focused ultrasound (tFUS) has emerged as a promising non-invasive technique for neuromodulation, offering advantages over existing methods...
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Molecularly imprinted polymers for high-specificity template molecule recognition
Molecularly imprinted polymers are created using calcium alginate microcapsules that can specifically recognize and bind template molecules like proteins. These biocompatible microcapsules are useful in medical diagnostics and food industry detection and can be reused after washing.
Background
Molecularly imprinted polymers (MIPs) have garnered significant...
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Hydrogel matrix technology for accelerating tissue-engineered dermal and vascular formation
A tissue-engineered dermal equivalent uses a hydrogel matrix with two distinct layers and mesenchymal stem cells (MSCs). One layer promotes blood vessel cell formation, while the other encourages dermal fibroblast development, facilitating vascular and dermal tissue creation from a single stem cell source.
Background
Severe skin injuries, such as...
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Highly porous recognitive polymer systems for controlled release of active agents
The invention is a porous, recognitive polymeric hydrogel system that releases active agents, like insulin, in response to specific triggers such as glucose. It uses methacrylic acid and sodium chloride to create a matrix that swells, cracks, or dissolves under low water or humidity conditions.
Background
The challenge of delivering active agents...
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Sustainable high molecular weight copolymers using the Vandenberg catalyst
This technology creates high molecular weight copolymers from lactones and epoxides using the Vandenberg catalyst. The process produces versatile, biodegradable materials with unique thermal properties and potential applications in environmental and biomedical fields.
Background
Copolymerization of lactones and epoxides is a crucial area of research...
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Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability.
Background
HME is a widely used technique in the pharmaceutical...
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