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Biocompatible proteoliposome technology for enhanced wound healing and reduced inflammation in diabetic patients
Syndesomes—lipid vesicles with embedded syndecan-4 and PDGF-BB—enhance wound healing by promoting cellular activities, reducing inflammation, and improving tissue regeneration. They are particularly effective in diabetic and obese models, supporting re-epithelialization and angiogenesis.
Background
Chronic non-healing wounds, particularly...
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Pegylated aminoglycoside compounds for enhanced treatment of biofilm infections
Pegylated aminoglycoside compounds, like m-PEG-tobramycin, combine antibiotics with polyethylene glycol to enhance solubility, stability, and bioavailability, effectively penetrating and disrupting biofilm infections resistant to standard treatments.
Background
Biofilm-associated infections present a significant challenge in medical and industrial...
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Engineered polypeptides for enhanced integrin binding and antigen delivery
Engineered recombinant Invasin polypeptides have been modified to enhance integrin binding and resist intestinal proteolysis, facilitating effective oral delivery of therapeutics, such as vaccines, by targeting M cells in the gut for improved immune responses.
Background
The challenge of delivering therapeutics such as vaccines effectively across...
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Improving the microbiome health of bees
Genetically engineered bacteria from the microbiome of bees are used to produce RNA interference (RNAi) molecules and other genetic tools to target and downregulate specific genes in bees or their pathogens. By reducing pathogen loads and altering gene expression of bees, this technology can combat threats to bee population, like colony collapse disorder,...
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Boosting bee health
A cocktail of native gut bacteria promotes health and pathogen resistance in bees
Problem
Honeybees and bumblebees play a crucial role in agricultural pollination, which is essential for human food production. Unfortunately, honeybee populations have experienced significant declines in the United States and around the world over the past decade. These...
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Low-cost fluorescent reporters for nuclease activity detection
Problem
DNA cleavage or nuclease activity detection is important in many forms of nucleic acid amplification tests. The current detection technologies rely on the use of fluorescence resonance energy transfer (FRET) reporters that light up upon digestion, such as the Taqman® probe and the DNaseAlert®. Although these FRET reporters well serve...
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