Polymeric network technology for controlled delivery of active agents

The technology involves a polymeric network designed for controlled delivery of active agents, triggered by the binding of specific molecules. This interaction reduces the structural integrity of the polymer at designated micro- or nanovacuoles, causing it to rupture and release the agents.

Background

Controlled delivery of active agents within polymeric networks is a significant challenge in various fields, including pharmaceuticals, agriculture, and consumer products. Traditional methods often rely on passive diffusion or external triggers like pH or temperature changes, which can lead to premature release or require complex administration protocols. Additionally, gelatinous polymers used for drug delivery tend to swell in the presence of solvents, leading to uncontrolled leakage of the payload.

This lack of precision in release timing and dosage can reduce the efficacy of the active agent and increase the risk of side effects. Furthermore, existing systems often struggle with maintaining structural integrity, resulting in inconsistent delivery and reduced reliability. Therefore, there is a pressing need for advanced materials and methods that can provide controlled, targeted, and reliable release of active agents in response to certain specific molecular triggers.

Technology description

The technology involves a sophisticated system for the controlled delivery of active agents within a polymeric network. This system is activated by the binding of a specific molecule which reduces the structural integrity of the polymer at designated micro- or nanovacuoles. The polymeric network, which can be a polymer or gel, contains these vacuoles that are imprinted to recognize a specific molecule. Upon binding, internal stresses are induced, causing the network to rupture and release the active agent. The network is designed to swell minimally (2% to 20% of its dried volume) in the presence of a solvent alone, ensuring that the payload is released only upon recognition of the target molecule.

Additionally, multilayer structures can be created where different layers recognize different molecules, allowing for sequential or controlled release of multiple agents. This system can be applied in pharmaceuticals, cosmetics, and household products, tailored to release drugs, fragrances, or detergents upon exposure to specific triggers.

This technology is differentiated by its ability to provide highly controlled and targeted release of active agents. Unlike traditional delivery systems that may leak or release their payload prematurely, this system ensures that the active agent is released only upon the specific recognition of a target molecule. This level of control and specificity in the release mechanism sets this technology apart from conventional delivery systems, offering significant advantages in terms of efficiency and effectiveness in delivering active agents.