Search results for life+sciences+%3e+therapeutics+%3e+manufacturing+platform

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Inhaled formulations of the NSAID indomethacin
Background Patients suffering from headache and migraine have a limited list of thera­peutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...
BioPod: A platform for increasing efficiency and reducing costs of biomanufacturing
Problem statement Biology can be harnessed to produce a large share of the global economy’s physical materials, potentially with improved performance and sustainability. Fermentation, for centuries used to brew beer and make bread, is now being used to create high-value ingredients such as collagen and spider silk. According to McKinsey, biologically...
Use of drug solvates in thermal processes to make solid dispersions at lower processing temperature
An improved manufacturing approach expands possibilities for poorly soluble drugs Description Increasing the solubility and bioavailability of poorly water-soluble drug candidates is critical to successful drug development and translation. While 90% of drug candidates in development and 40% of all marketed drugs exhibit poor solubility, this remains...
DosePlus: A pharmaceutical 3D-printing platform for flexible and precise dosages
Problem Innovations in 3D printing have caused a paradigm shift in the design and manufacture of pharmaceuticals. By allowing for on-demand production of custom dosages, 3D printing has the potential to transform the field of personalized medicine and the economics of pharmaceutical manufacturing.1 However, existing 3D printing techniques for drug manufacturing...
Enhanced dissolution of drug compositions using porous carriers made by thermal process
New pharmaceutical manufacturing process improves bioavailability of poorly soluble drugs Description Solubility of pharmaceuticals is crucial to absorption by the human intestine and, ultimately, efficacy of the drug. Over 90% of new chemical entities being considered for drug development have low solubility. Amorphous solid dispersions (ASDs) are...