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Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution.
Background
Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
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DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance.
Background
The field of biochemical research and medical diagnostics increasingly...
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Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by substituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence.
Background
Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
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Computing system for cognitive impairment detection
This computing system can detect cognitive impairment. It presents memory and verbal tasks, analyzes user input, and provides care recommendations.
Background
Digital healthcare solutions are being intensely studied for rapid identification and effective management of patients with Alzheimer’s disease and related disorders (ADRD).
Early detection...
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Antibody and T-cell receptor sequencing for identifying cancer-specific immune receptors
This tech identifies cancer-specific antibodies and T-cell receptors by sequencing mRNA from immune cells in a patient’s tumor-draining lymph nodes and comparing the sequences with the patient’s antibody polypeptide data.
Background
Cancer immunotherapy has emerged as a promising approach to treating various types of cancers. This field...
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Modified kynureninase enzymes for cancer therapy
This invention describes modified kynureninase enzymes, particularly human enzymes, for degrading kynurenine. These enzymes can be used in compositions and methods for treating cancer by depleting kynurenine levels.
Background
Cancer immunotherapy has emerged as a promising approach to treating a wide range of malignancies. The goal of immunotherapy...
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Blood-brain barrier penetrant therapeutic delivery with biomacromolecule-tagged constructs
This technology uses nanoscale constructs tagged with biomacromolecules like peptides, nucleic acids, and carbohydrates to deliver therapeutic agents across the blood-brain barrier, enhancing drug delivery to the brain while minimizing off-target effects.
Background
The blood-brain barrier (BBB) is a critical physiological structure that serves to...
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Calibration technology for accurate quantification of biomolecules
This method enhances biomolecular analysis by providing reliable references, improving research and clinical quantification accuracy. Here, calibration standards with known glycerolipid compositions are used in mass spectrometry to accurately quantify these biomolecules in samples.
Background
Glycerolipids (GLs), which consist of a glycerol backbone...
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Biomimetic microfluidic device in cell culture studies
This technology is a microfluidic cell culture device that replicates human organ functions by using multiple microchannels and membranes to simulate different tissue environments in cell culture studies. It enables advanced research in drug testing, disease modeling, and personalized medicine.
Background
Cell culture technology faces significant...
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Microfluidic devices for rapid and automated sample processing
Microfluidic devices enable rapid, automated processing and manipulation of multiple sample populations without cross-contamination, enhancing experimental throughput and quality for model organisms like C. elegans.
Background
Microfluidic technology has emerged as a critical field within biomedical and biochemical research, offering precise control...
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