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Label-free molecular data storage using oligourethanes and desorption spray ionization
Background
The explosion of digital information—from scientific data to entertainment media—has outpaced the capabilities of traditional storage technologies. Magnetic hard drives, solid-state drives, and optical media face limitations in terms of environmental robustness, long-term retention, and energy efficiency. Large-scale data centers...
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DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background
Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
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Tunable dual-network viscoelastic hydrogels for tissue engineering and cell modeling
Background
Advances in tissue engineering and regenerative medicine continue to emphasize the importance of recreating physiologically relevant mechanical environments for in vitro studies. Cellular behavior, tissue regeneration, and drug response are all significantly influenced by the viscoelasticity of the surrounding matrix. While native tissues...
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Tracking intractable single-cell fusion events via two-color DNA barcoding platform
CMDuo is a DNA barcoding system using two colors to monitor individual cell fusion in cancer cells. It enables detailed tracking and analysis of how cells merge, helping clarify tumor behavior and identify potential treatment targets.
Background
The study of cell-cell fusion is a critical area in cancer research, particularly concerning triple-negative...
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Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution.
Background
Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
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DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance.
Background
The field of biochemical research and medical diagnostics increasingly...
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Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by substituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence.
Background
Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
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Computing system for cognitive impairment detection
This computing system can detect cognitive impairment. It presents memory and verbal tasks, analyzes user input, and provides care recommendations.
Background
Digital healthcare solutions are being intensely studied for rapid identification and effective management of patients with Alzheimer’s disease and related disorders (ADRD).
Early detection...
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Antibody and T-cell receptor sequencing for identifying cancer-specific immune receptors
This tech identifies cancer-specific antibodies and T-cell receptors by sequencing mRNA from immune cells in a patient’s tumor-draining lymph nodes and comparing the sequences with the patient’s antibody polypeptide data.
Background
Cancer immunotherapy has emerged as a promising approach to treating various types of cancers. This field...
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Modified kynureninase enzymes for cancer therapy
This invention describes modified kynureninase enzymes, particularly human enzymes, for degrading kynurenine. These enzymes can be used in compositions and methods for treating cancer by depleting kynurenine levels.
Background
Cancer immunotherapy has emerged as a promising approach to treating a wide range of malignancies. The goal of immunotherapy...
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