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Spray-dried RNA-lipid nanoparticle dry powder technology for stable and inhalable delivery of therapeutics
Background
Messenger RNA (mRNA) therapeutics have rapidly emerged as a transformative method for vaccination and gene therapy. However, the field faces significant hurdles related to the instability of mRNA molecules, which are highly susceptible to enzymatic degradation. Lipid nanoparticles (LNPs) have become the delivery vehicle of choice, shielding...
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KinetiSol powder ejection for low-temperature formulation of thermolabile APIs
Background
Many emerging drug candidates suffer from poor aqueous solubility and heat sensitivity, making them difficult to formulate using conventional manufacturing techniques. These challenges are especially problematic for inhalation and nasal drug delivery, where fine particle size and chemical stability are essential for therapeutic performance.
Existing...
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Layered simulation software for optimizing freeze-drying of porous particle beds
Background
Freeze-drying is a critical process in pharmaceutical, nutraceutical, and food manufacturing where product stability and preservation are paramount. Despite its widespread use, traditional freeze-drying remains inefficient, requiring long cycle times and high energy input. These limitations become even more pronounced during scale-up, where...
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Pressure-assisted 3D printing for tunable micro/nanoparticle drug delivery
Background
In the realm of drug delivery and biomedical therapies, advanced formulations are essential for improving treatment efficacy, minimizing systemic toxicity, and achieving precise therapeutic targeting. Technologies capable of encapsulating and preserving the bioactivity of small molecules, proteins, and live cells are particularly critical...
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Three-component secretion system for extracellular delivery of folded proteins in gram-negative bacteria
Background
Efficient production and secretion of functional proteins are essential to a wide range of applications in biotechnology and medicine, from therapeutic protein delivery to industrial enzyme manufacturing. Gram-negative bacteria such as E. coli are commonly used expression hosts due to their rapid growth, affordability, and genetic flexibility.
However,...
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SMART 3D-printed proliposomes for stable, targeted drug delivery
Background
In the realm of drug delivery, particularly for cancer therapeutics, there is a growing demand for robust nanocarrier systems that offer improved targeting, extended shelf-life, and consistent efficacy. Liposomes have historically served as biocompatible delivery vehicles; however, they often suffer from formulation instability and limited...
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Multi-material electrospinning system for 3D-printed fiber architectures
Background
Electrospinning and additive manufacturing have become increasingly important in fields such as biotechnology, pharmaceuticals, and tissue engineering, where there is growing demand for complex fiber architectures and multifunctional material systems. However, traditional electrospinning methods struggle to meet the precision, scalability,...
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Lipid-coated granule feedstock for high-precision pharmaceutical 3D printing
Background
The field of pharmaceutical manufacturing is rapidly evolving to meet increasing demands for personalized drug delivery, precise dosage forms, and consistent controlled-release profiles. As healthcare shifts toward individualized treatment plans, clinicians and researchers are seeking advanced manufacturing solutions that deliver compact,...
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Scalable artificial tissue engineering for tunable 3D structures and selective membranes
This invention uses a scalable droplet interface bilayer method to create customizable artificial tissues from water droplets. The tissues are tunable for conductivity, stiffness, and self-healing, enabling applications like 3D bioprinting and selective electrically driven separations.
Background
The field of tissue engineering has long sought to...
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Advanced multi-channel controlled pneumatic printheads for 3D printing and particle fabrication
MAGIC printheads are customizable multi-channel pneumatic systems for 3D printing that create precise pharmaceutical and biological micro-particles. They enable controlled mixing and extrusion, accommodate various materials, and enhance drug delivery and biomedical applications.
Background
Producing micro- and nanoparticles for pharmaceutical and...
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