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Engineered microbial antigen-presenting system for targeted T cell activation
Background
Targeted immunotherapy depends on the ability to modulate specific T cell populations to fight chronic infections, cancers, and autoimmune diseases. Achieving precise control over T cell activation is essential for generating effective immune responses while minimizing off-target effects. Traditional vaccines and existing antigen-presenting...
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One-pot assembly of long, modified DNA via scaffolded oligo ligation
Background
As synthetic biology advances, the need for efficient construction of long, chemically modified DNA has become increasingly critical across applications such as gene editing, DNA data storage, epigenetics, and personalized therapeutics. These technologies require precise, site-specific incorporation of chemical tags into DNA strands that...
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Modular protein degradation platform bypassing ubiquitination
Background
Targeted protein degradation is rapidly emerging as a powerful therapeutic approach for eliminating disease-causing proteins in cancer, neurodegenerative conditions, autoimmune disorders, and viral infections. By removing, rather than inhibiting, harmful proteins, this strategy enables direct and sustained therapeutic effects....
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Label-free molecular data storage using oligourethanes and desorption spray ionization
Background
The explosion of digital information—from scientific data to entertainment media—has outpaced the capabilities of traditional storage technologies. Magnetic hard drives, solid-state drives, and optical media face limitations in terms of environmental robustness, long-term retention, and energy efficiency. Large-scale data centers...
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DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background
Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
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Tunable dual-network viscoelastic hydrogels for tissue engineering and cell modeling
Background
Advances in tissue engineering and regenerative medicine continue to emphasize the importance of recreating physiologically relevant mechanical environments for in vitro studies. Cellular behavior, tissue regeneration, and drug response are all significantly influenced by the viscoelasticity of the surrounding matrix. While native tissues...
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Tracking intractable single-cell fusion events via two-color DNA barcoding platform
CMDuo is a DNA barcoding system using two colors to monitor individual cell fusion in cancer cells. It enables detailed tracking and analysis of how cells merge, helping clarify tumor behavior and identify potential treatment targets.
Background
The study of cell-cell fusion is a critical area in cancer research, particularly concerning triple-negative...
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DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance.
Background
The field of biochemical research and medical diagnostics increasingly...
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Enhanced fluorescence via DNA aptamer optimization
This invention improves the fluorescence of DNA-based aptamers by substituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence.
Background
Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...
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Computing system for cognitive impairment detection
This computing system can detect cognitive impairment. It presents memory and verbal tasks, analyzes user input, and provides care recommendations.
Background
Digital healthcare solutions are being intensely studied for rapid identification and effective management of patients with Alzheimer’s disease and related disorders (ADRD).
Early detection...
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