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High-throughput detection of single nucleotide polymorphisms (SNPs) via CRISPR-based diagnostic platform
This CRISPR-based technology enables precise detection of single nucleotide polymorphisms (SNPs) in nucleic acids by using programmed mismatches between CRISPR RNA and target nucleic acids, facilitating high-throughput, quantitative, and point-of-care diagnostics.
Background
Single nucleotide polymorphisms (SNPs) play a crucial role in disease susceptibility,...
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High-speed laser scanning and microfluidic device system for automated 3D imaging and specimen manipulation
The high-speed laser scanning microscopy platform enables rapid, automated 3D imaging of biological specimens, offering flexible control over imaging parameters, large field-of-view, and high-resolution imaging, ideal for studying dynamic processes in living organisms.
Background
Laser scanning systems, particularly in the field of microscopy, have...
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Human enzyme-mediated depletion of serine in cancer
Engineered human serine dehydratase enzymes are designed to efficiently degrade serine, an amino acid crucial to cancer cell metabolism, and inhibit cancer growth. These enzymes, with improved stability, activity, and bioavailability, offer a targeted cancer treatment option with fewer adverse effects.
Background
Traditional chemotherapeutic...
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Engineered sugar uptake in yeast cells
The technology focuses on engineered transporter proteins that enhance the uptake of specific monosaccharides like xylose and arabinose into yeast cells, improving their efficiency and selectivity for biofuel and biochemical production.
Background
The efficient conversion of lignocellulosic biomass into biofuels and biochemicals is a critical...
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RealCooL: rapid thermal control of liquids
Problem statement
Current technologies to heat or cool liquids, such as water baths to rewarm or pasteurize human milk, suffer from slow heating times and inability to control temperature accurately. There is a need for a device that is faster, more accurate, and safer for babies and caregivers to use.
Solution
RealCooL was developed by engineers...
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Degradons: target proteins for degradation without ubiquitination
Problem
Targeting specific proteins for degradation is an area of intense research for the treatment of disease. The majority of currently available technologies, such as PROTACs, induce degradation through ubiquitination of target proteins by binding to both the target protein and ubiquitin ligases. However, this requires a ubiquitin ligase to efficiently...
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