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Ultrasound-triggered anesthetic drug delivery for on-demand chronic pain management
A nanoparticle-based ultrasound-responsive drug delivery system for precise, controlled, and targeted therapeutic release
This technology uses ultrasound-triggered nanoparticles to deliver local anesthetics precisely and safely for pain management, reducing side effects and opioid risks, with potential for targeted delivery of other drugs in cancer,...
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Wearable electronic tattoo for real-time hydration monitoring
Background
Accurate hydration assessment is essential for maintaining health, performance, and safety; even mild dehydration can impair cognition, physical function, and cardiovascular stability. Populations such as older adults, athletes, outdoor laborers, military personnel, and individuals with limited access to clinical care are particularly...
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Wearable ultrasound and EEG patch for noninvasive REM sleep enhancement
Background
Sleep is essential for emotional regulation, cognitive function, and overall health. Chronic sleep disruption, prevalent among individuals with PTSD, shift workers, and military personnel, affects tens of millions and contributes to serious long-term health consequences. Despite growing awareness, most existing sleep aid technologies fail...
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Microfluidic evaporator concentrator for increasing analyte concentration in small-volume aqueous samples
Background
Point-of-care diagnostics, environmental monitoring, and biomanufacturing increasingly require the detection of low concentrations of biomolecules and other non-volatile analytes in aqueous samples, yet many portable analytical systems lack sufficient sensitivity without a preconcentration step.
Existing methods such as centrifugal evaporation,...
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Dual-stiffness passive prosthetic ankle for direction-dependent stability
Background
Lower-limb amputees often struggle to maintain balance and stability during everyday activities, particularly when turning or navigating uneven surfaces, because the loss of natural ankle musculature and proprioception limits their ability to adapt to changing loads and directions. Most prosthetic ankles provide a single fixed stiffness,...
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Real-time optical microdialysis sensor for continuous metabolite monitoring
Background
Continuous, real-time monitoring of small molecule metabolites in living tissue is critical for managing conditions like traumatic brain injury (TBI), where rapid shifts in metabolism can precede clinical deterioration. Traditional methods such as microdialysis allow for extracellular fluid sampling of metabolites like glucose, lactate,...
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Bio-inspired continuum robot for advanced minimally invasive surgery
Background
Minimally invasive surgery has transformed patient care by reducing trauma, accelerating recovery, and improving outcomes, especially in delicate fields such as fetal surgery, pediatric procedures, and advanced endoscopy. These procedures demand instruments that can navigate tightly constrained and highly curved anatomical pathways with...
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A microneedle-based resonant sensor system for continuous, wireless monitoring of wound and physiological states
This technology uses gold-coated microneedles and wireless sensors to directly sample wound fluid, detecting infection and other changes in real time. Data is analyzed with machine learning and sent to clinicians for early, continuous wound monitoring.
Background
Wound monitoring is a critical aspect of healthcare, especially for patients recovering...
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Ultrathin graphene electronic tattoos for continuous, high-fidelity, and unobtrusive physiological monitoring
Graphene electronic tattoos are ultrathin, flexible, and transparent sensors that stick to skin like temporary tattoos to comfortably and accurately monitor vital signs, brain and muscle activity, hydration, and temperature for long-term, unobtrusive health tracking.
Background
Wearable physiological monitoring technologies have become increasingly...
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WAVE: Wearable Analog-processed Vascular Echography
Background
The field of ultrasonic imaging is crucial for non-invasive medical diagnostics, offering detailed insights into internal body structures and physiological processes. There is a significant need for continuous, long-term monitoring of hemodynamic parameters, such as blood volume and vessel dynamics, particularly for early detection...
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