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Scalable artificial tissue engineering for tunable 3D structures and selective membranes
This invention uses a scalable droplet interface bilayer method to create customizable artificial tissues from water droplets. The tissues are tunable for conductivity, stiffness, and self-healing, enabling applications like 3D bioprinting and selective electrically driven separations.
Background
The field of tissue engineering has long sought to...
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Pharmaceutical manufacturing of the future: a continuous 3D printing approach for personalized medicine
Background
Driven by personalized medicine, 3D printing has emerged as a promising technology for creating tailored pharmaceutical dosage forms. One of its methods, Fused Deposition Modeling (FDM), is particularly notable for its ability to produce complex geometries using thermoplastic polymers. However, current FDM processes face significant...
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Advanced multi-channel controlled pneumatic printheads for 3D printing and particle fabrication
MAGIC printheads are customizable multi-channel pneumatic systems for 3D printing that create precise pharmaceutical and biological micro-particles. They enable controlled mixing and extrusion, accommodate various materials, and enhance drug delivery and biomedical applications.
Background
Producing micro- and nanoparticles for pharmaceutical and...
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Enhanced pharmaceutical co-crystal production via continuous dielectric heating and hot melt extrusion method
CoMIDEx uses microwave heating and extrusion to create drug cocrystals, enhancing their solubility and effectiveness. It’s a continuous, eco-friendly process that improves medicine availability without using solvents.
Background
Pharmaceutical development heavily relies on active pharmaceutical ingredients (APIs) to provide therapeutic benefits....
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Optimized inhalation formulation of clofazimine and amikacin for targeted treatment of respiratory infections
The invention describes a pharmaceutical composition combining clofazimine and amikacin for inhalation to treat respiratory diseases like tuberculosis. This formulation enhances drug delivery to the lungs, improving efficacy and reducing systemic side effects.
Background
Bacterial infections, particularly those caused by mycobacteria such as Mycobacterium...
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Recognitive biodegradable nanoparticles for targeted in vivo diagnostics and therapeutics
Recognitive biodegradable nanoparticles combine molecularly imprinted polymers with biodegradable cores to detect specific target molecules like proteins for in vivo diagnostics. They offer high affinity, selectivity, lower production costs, and reduced immunologic response.
Background
The field of molecularly imprinted polymers (MIPs) involves creating...
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3D printing technology for customized pharmaceutical dosage forms
The invention utilizes 3D printing with selective laser sintering to create pharmaceutical tablets from amorphous solid dispersions, enhancing drug solubility and bioavailability without additional excipients, allowing customizable drug release rates and unique dosage forms.
Background
In the pharmaceutical industry, the development of drugs with...
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Controlled-release drug formulation
Background
The field of pharmaceutical technology has made significant strides in developing drug delivery systems that optimize the therapeutic effects of medications while minimizing side effects. One such advancement is the creation of modified-release formulations, which are designed to release a drug at a predetermined rate, thereby maintaining...
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Inhaled formulations of the NSAID indomethacin
Background
Patients suffering from headache and migraine have a limited list of therapeutic options that often is shortened by issues stemming from tolerability or efficacy. For this reason, there is a big push in the industry to develop inhaled treatments for these disorders. The invention described here repurposes a compound with known efficacy...
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Use of drug solvates in thermal processes to make solid dispersions at lower processing temperature
An improved manufacturing approach expands possibilities for poorly soluble drugs Description Increasing the solubility and bioavailability of poorly water-soluble drug candidates is critical to successful drug development and translation. While 90% of drug candidates in development and 40% of all marketed drugs exhibit poor solubility, this remains...
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