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CRISPR-enhanced biosensor for ultrasensitive and multiplexed enzyme activity sensing
Background
Proteases play essential roles in numerous biological and pathological processes, including inflammation, cancer metastasis, neurodegeneration, and infectious disease. Specific protease activity serves as a valuable biomarker for disease progression, treatment monitoring, and drug development. However, existing detection methods are often...
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Modular robotic-assisted system for enhanced endoscope and colonoscope navigation
Background
Endoscopic and colonoscopic procedures are essential for diagnosing and treating a wide range of internal conditions, from gastrointestinal bleeding to early-stage cancers. These minimally invasive techniques depend on the clinician’s ability to skillfully navigate complex, tortuous anatomical structures to achieve clear visualization...
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Soft inflatable robot for in-pipe inspection
Background
Pipeline infrastructure in oil and gas, water systems, and chemical processing requires regular internal inspections to detect corrosion, blockages, and structural damage. However, many pipelines are narrow, tortuous, and operate under variable pressure and flow conditions, making access with conventional tools difficult. Rigid robotic crawlers...
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Technology for fabricating dense sapphire nanostructures using near‑field focusing of ultrafast lasers
Background
Nanostructuring ultrahard materials like sapphire is challenging due to their inherent hardness and chemical stability, which complicate the precise modification and removal of material. Traditional approaches such as multilayer masking, low-power dry etching, and direct ultrafast laser processing have struggled to achieve the fine,...
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Cytokine analysis for seronegative autoimmune epilepsy diagnosis
This study found a unique profile of 14 elevated cytokines, potential biomarkers, in patients with a specific type of epilepsy (snAAE) that doesn’t respond to traditional antibody tests.
Background
Autoimmune-associated epilepsy (AAE) is a significant contributor to drug-resistant epilepsy cases, characterized by a positive response to...
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Wearable tongue tracker for silent speech interfaces
MagTrack is a lightweight, wearable device that utilizes magnetic fields to track tongue movements, enabling silent speech recognition and other applications like speech therapy.
Background
Silent speech interfaces (SSIs) aim to restore communication for individuals who have lost their voice but retain the ability to articulate, such as those who...
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Computing system for cognitive impairment detection
This computing system can detect cognitive impairment. It presents memory and verbal tasks, analyzes user input, and provides care recommendations.
Background
Digital healthcare solutions are being intensely studied for rapid identification and effective management of patients with Alzheimer’s disease and related disorders (ADRD).
Early detection...
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Kinematic data analysis for stress detection
This technology uses movement data from laparoscopic instruments to detect stress levels in surgeons in near real-time. An AI model analyzes the data, identifying movement patterns associated with stress, and can be integrated into robotic surgical platforms for feedback and guidance.
Background
Laparoscopic surgery is a complex and demanding field...
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High-throughput RNA sequencing technology for comprehensive transcriptome profiling and biomarker identification in inflammatory breast cancer
The technology utilizes TGIRT-seq, a high-throughput RNA sequencing method, to identify potential biomarkers for inflammatory breast cancer by profiling coding and non-coding RNAs in tumor and blood samples, aiding in diagnosis and disease monitoring.
Background
Inflammatory breast cancer (IBC) is recognized as the most aggressive form of breast cancer,...
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Harnessing the Type III-Dv CRISPR-Cas system for targeted RNA modification and detection
The Type III-Dv CRISPR-Cas system is a genetic tool designed for precise RNA targeting and cleavage. It uses a complex of Cas proteins to bind and modify single-stranded nucleic acids, enabling applications in gene silencing and RNA detection.
Background
The field of CRISPR-Cas technology has revolutionized genetic engineering by providing precise...
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