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Cytokine analysis for seronegative autoimmune epilepsy diagnosis
This study found a unique profile of 14 elevated cytokines, potential biomarkers, in patients with a specific type of epilepsy (snAAE) that doesn’t respond to traditional antibody tests.
Background
Autoimmune-associated epilepsy (AAE) is a significant contributor to drug-resistant epilepsy cases, characterized by a positive response to...
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Wearable tongue tracker for silent speech interfaces
MagTrack is a lightweight, wearable device that utilizes magnetic fields to track tongue movements, enabling silent speech recognition and other applications like speech therapy.
Background
Silent speech interfaces (SSIs) aim to restore communication for individuals who have lost their voice but retain the ability to articulate, such as those who...
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Computing system for cognitive impairment detection
This computing system can detect cognitive impairment. It presents memory and verbal tasks, analyzes user input, and provides care recommendations.
Background
Digital healthcare solutions are being intensely studied for rapid identification and effective management of patients with Alzheimer’s disease and related disorders (ADRD).
Early detection...
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Kinematic data analysis for stress detection
This technology uses movement data from laparoscopic instruments to detect stress levels in surgeons in near real-time. An AI model analyzes the data, identifying movement patterns associated with stress, and can be integrated into robotic surgical platforms for feedback and guidance.
Background
Laparoscopic surgery is a complex and demanding field...
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High-throughput RNA sequencing technology for comprehensive transcriptome profiling and biomarker identification in inflammatory breast cancer
The technology utilizes TGIRT-seq, a high-throughput RNA sequencing method, to identify potential biomarkers for inflammatory breast cancer by profiling coding and non-coding RNAs in tumor and blood samples, aiding in diagnosis and disease monitoring.
Background
Inflammatory breast cancer (IBC) is recognized as the most aggressive form of breast cancer,...
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Harnessing the Type III-Dv CRISPR-Cas system for targeted RNA modification and detection
The Type III-Dv CRISPR-Cas system is a genetic tool designed for precise RNA targeting and cleavage. It uses a complex of Cas proteins to bind and modify single-stranded nucleic acids, enabling applications in gene silencing and RNA detection.
Background
The field of CRISPR-Cas technology has revolutionized genetic engineering by providing precise...
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High-throughput detection of single nucleotide polymorphisms (SNPs) via CRISPR-based diagnostic platform
This CRISPR-based technology enables precise detection of single nucleotide polymorphisms (SNPs) in nucleic acids by using programmed mismatches between CRISPR RNA and target nucleic acids, facilitating high-throughput, quantitative, and point-of-care diagnostics.
Background
Single nucleotide polymorphisms (SNPs) play a crucial role in disease susceptibility,...
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Stabilized coronavirus spike proteins for enhanced vaccine efficacy
Engineered proteins with stabilized coronavirus spike protein ectodomains enhance immune response and are useful in diagnostics, screening, and vaccines against coronaviruses like SARS-CoV-2 by maintaining prefusion conformation, potentially producing cross-reactive antibodies.
Background
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has...
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Engineered chimeric fusion proteins
Enhancing stability and expression for improved vaccines and diagnostics in hMPV and RSV
The invention describes engineered chimeric F proteins combining sequences from human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) to enhance stability and expression. These proteins are useful in vaccines, diagnostics, and antibody screening.
Background
Respiratory...
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Blood pressure regulation via thermal control during sleep
This technology uses a stimulating device and blood pressure monitor to regulate blood flow and lower blood pressure during sleep through targeted thermal stimulation, promoting cardiovascular health by integrating into a climate-controlled bed.
Background
High blood pressure, or hypertension, is a significant health concern linked to various cardiovascular...
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