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Use of drug solvates in thermal processes to make solid dispersions at lower processing temperature
An improved manufacturing approach expands possibilities for poorly soluble drugs Description Increasing the solubility and bioavailability of poorly water-soluble drug candidates is critical to successful drug development and translation. While 90% of drug candidates in development and 40% of all marketed drugs exhibit poor solubility, this remains...
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DosePlus: A pharmaceutical 3D-printing platform for flexible and precise dosages
Problem Innovations in 3D printing have caused a paradigm shift in the design and manufacture of pharmaceuticals. By allowing for on-demand production of custom dosages, 3D printing has the potential to transform the field of personalized medicine and the economics of pharmaceutical manufacturing.1 However, existing 3D printing techniques for drug manufacturing...
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Enhanced dissolution of drug compositions using porous carriers made by thermal process
New pharmaceutical manufacturing process improves bioavailability of poorly soluble drugs Description Solubility of pharmaceuticals is crucial to absorption by the human intestine and, ultimately, efficacy of the drug. Over 90% of new chemical entities being considered for drug development have low solubility. Amorphous solid dispersions (ASDs) are...
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Efficient 3D printing manufacturing platform for poorly soluble drugs
Novel 3D printing approach enables single-step manufacturing of poorly soluble drugsBackgroundA large number of pharmaceuticals are eliminated by the body due to their poor water solubility. This limits effectiveness because the drugs cannot be efficiently absorbed. To overcome this, drugs can be administered in an amorphous state rather than a crystalline...
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